There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ) disorders. including Spinocerebellar Ataxia Type-3 (SCA3). Here. we augment the proteostasis network of Drosophila SCA3 models with Hsp104. https://www.secondgearwncers.shop/product-category/knives/